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1. Biomedical articles (top 50; 2007 to 2012)

1. |||||||||. 100%  Kusuhara K: [Erythema infectiosum]. Nihon Rinsho; 2007 Mar 28;65 Suppl 3:343-8

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Erythema infectiosum].

[MeSH-major] Erythema Infectiosum

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[Affiliation] Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University.

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[ISSN] 0047-1852

[Journal-full-title] Nihon rinsho. Japanese journal of clinical medicine

[ISO-abbreviation] Nippon Rinsho

[Language] jpn

[Publication-type] Journal Article; Review

[Publication-country] Japan

[Number-of-references] 21

   

2. ||||||||.. 82%  Sachan D: Erythema infectiosum rash. Indian Pediatr; 2011 Apr 7;48(4):338

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Erythema infectiosum rash.

[MeSH-major] Erythema Infectiosum / virology. Parvovirus B19, Human / isolation & purification

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[Affiliation] PGIMER Dr RML Hospital, New Delhi, India. deepaksachan26@yahoo.com send email

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[ISSN] 0974-7559

[Journal-full-title] Indian pediatrics

[ISO-abbreviation] Indian Pediatr

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] India

   

3. |||||||... 72%  Oliveira MJ, Cordeiro MT, Costa FM, Murakami G, Silva AM, Travassos RC, Magalhães V: [Frequency of measles, rubella, dengue and erythema infectiosum among suspected cases of measles and rubella in the State of Pernambuco between 2001 and 2004]. Rev Soc Bras Med Trop; 2008 Jul-Aug;41(4):338-44

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Frequency of measles, rubella, dengue and erythema infectiosum among suspected cases of measles and rubella in the State of Pernambuco between 2001 and 2004].

[Transliterated title] Freqüência de sarampo, rubéola, dengue e eritema infeccioso entre casos suspeitos de sarampo e rubéola no estado de Pernambuco, no período de 2001 a 2004.

This study had the aim of investigating the frequency of measles, rubella, dengue and erythema infectiosum among suspected cases of measles and/or rubella in the state of Pernambuco, Brazil.

A total of 1,161 serum samples collected between 2001 and 2004 were tested for these four viral diseases, using enzyme immunoassays to detect IgM antibodies.

Out of this total, 276 (23.8%) samples were positive for one of the four viral diseases analyzed.

There were 196 positive cases (16.9%) for dengue, 38 (3.3%) for erythema infectiosum (parvovirus B19), 32 (2.8%) for rubella and 10 (0.9%) for measles.

Among the suspected cases of measles and rubella, dengue infection was the most frequent, followed by parvovirus B19.

The similarity of the clinical manifestations among rash diseases contributes towards making it difficult to diagnose measles, rubella, dengue and erythema infectiosum on clinical grounds alone.

It must be emphasized that the four tests used were insufficient for diagnosing 76.2% of the febrile and rash diseases notified.

This is the first study bringing evidence of human parvovirus B19 circulation in Pernambuco.

[MeSH-major] Antibodies, Viral / blood. Dengue / epidemiology. Erythema Infectiosum / epidemiology. Immunoglobulin M / blood. Measles / epidemiology. Rubella / epidemiology

[MeSH-minor] Adolescent. Adult. Brazil / epidemiology. Child. Child, Preschool. Cross-Sectional Studies. Dengue Virus / immunology. Female. Humans. Immunoenzyme Techniques. Infant. Male. Morbillivirus / immunology. Parvovirus B19, Human / immunology. Rubella virus / immunology. Seasons

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[Affiliation] Programa de Pós-Graduação em Medicina Tropical, Universidade Federal de Pernambuco, Recife, PE, Brasil. mariajosecouto@hotmail.com send email

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[ISSN] 1678-9849

[Journal-full-title] Revista da Sociedade Brasileira de Medicina Tropical

[ISO-abbreviation] Rev. Soc. Bras. Med. Trop.

[Language] por

[Publication-type] English Abstract; Journal Article

[Publication-country] Brazil

[Chemical-registry-number] 0 / Antibodies, Viral; 0 / Immunoglobulin M

   

4. |||||||... 70%  Dobec M, Juchler A, Flaviano A, Kaeppeli F: Prolonged parvovirus b19 viremia in spite of neutralizing antibodies after erythema infectiosum in pregnancy. Gynecol Obstet Invest; 2007;63(1):53-4

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Prolonged parvovirus b19 viremia in spite of neutralizing antibodies after erythema infectiosum in pregnancy.

OBJECTIVE: To check the clearance of parvovirus B19 in the course of the development of neutralizing antibodies after Erythema infectiosum in pregnancy.

METHODS: Parvovirus B19 serology (Parvovirus B19 IFA IgG, IgM Antibody Test Kit, Biotrin, Ireland and Immunoblot RIDA Blot Parvovirus B19, R-Biopharm, Germany) and polymerase chain reaction (PCR Parvovirus B19, Roche Diagnostics, Switzerland) were performed in eight predelivery sera, one cord blood sample and one serum 2 months after delivery.

RESULTS: Acute parvovirus B19 infection in pregnancy was diagnosed by seroconversion in the IgM and IgG antibody class and detection of viral DNA by PCR.

Despite the presence of neutralizing antibodies, PCR gave positive results in all subsequent sera including the cord blood sample and the post-delivery sample 7 months after primary infection.

Neonatal examination on the 4th day after delivery was normal and no clinical sign of intrauterine infection was noted.

CONCLUSIONS: Prolonged parvovirus B19 viremia infection can be seen in spite of neutralizing IgG antibodies and in IgM negative patients.

Therefore, the presence of IgG antibodies in the absence of IgM antibodies should not always be interpreted as a past infection.

The infectivity of patients with persistent parvovirus B19 infection requires further studies.

[MeSH-major] Antibodies, Viral / blood. Erythema Infectiosum / immunology. Parvovirus B19, Human / immunology. Pregnancy Complications, Infectious / immunology. Viremia / immunology

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[Affiliation] Medica, Medizinische Laboratorien Dr. F. Kaeppeli, Zurich, Switzerland. m.dobec@medica-labor.ch send email

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[ISSN] 0378-7346

[Journal-full-title] Gynecologic and obstetric investigation

[ISO-abbreviation] Gynecol. Obstet. Invest.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Switzerland

[Chemical-registry-number] 0 / Antibodies, Viral

   

5. ||||...... 41%  Mandel ED: Erythema infectiosum: recognizing the many faces of fifth disease. JAAPA; 2009 Jun;22(6):42-6

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Erythema infectiosum: recognizing the many faces of fifth disease.

[MeSH-major] Erythema Infectiosum / diagnosis. Parvoviridae Infections / diagnosis

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[Affiliation] Seton Hall University, School of Health and Medical Sciences Physician Assistant Program, South Orange, New Jersey, USA.

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[ISSN] 1547-1896

[Journal-full-title] JAAPA : official journal of the American Academy of Physician Assistants

[ISO-abbreviation] JAAPA

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

   

6. |......... 8%  Takano T, Yamada K: Quantitation of human parvovirus B19 DNA by real-time polymerase chain reaction. Pediatr Int; 2007 Aug;49(4):459-62

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Quantitation of human parvovirus B19 DNA by real-time polymerase chain reaction.

BACKGROUND: There have been no reports on either the serial quantification of genomic copies in the various parvovirus B19 infections or the comparison of the viral amount in erythema infectiosum, unlike with that in other parvovirus B19 infections.

METHODS: A total of 19 children with parvovirus B19 infection were classified into a group of seven (group A) with erythema infectiosum and a group of 12 (group B) without erythema infectiosum, and their serum levels of parvovirus B19 DNA were quantified by real-time polymerase chain reaction.

A total of 30 boys and girls with some symptoms but no parvovirus B19 infection served as a control group (group C).

RESULTS: The amount of parvovirus B19 DNA differed significantly between groups A and C (P < 0.01) and between groups B and C (P < 0.01).

Erythema infectiosum developed in two patients of group B on the 6th and 29th days after onset when the amount of viral DNA was similar to that in group A.

CONCLUSIONS: The amount of parvovirus B19 DNA correlated well with the stage of infection, and its quantitation was useful for determining disease status and prognosis.

In parvovirus B19 infection, the viremia is associated with rare but varied pathological states different from erythema infectiosum, such as transient aplastic crisis, hemophagocytic syndrome, lupus-like syndrome, and papular-purpuric gloves and socks syndrome.

[MeSH-major] DNA, Viral / blood. Parvovirus B19, Human / chemistry

[MeSH-minor] Adolescent. Child. Erythema Infectiosum / blood. Female. Humans. Infant. Male. Polymerase Chain Reaction

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[Affiliation] Children's Medical Center, Showa University Northern Yokohama Hospital, Yokohama, Japan. tadamasatakano@dream.com send email

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[ISSN] 1328-8067

[Journal-full-title] Pediatrics international : official journal of the Japan Pediatric Society

[ISO-abbreviation] Pediatr Int

[Language] eng

[Publication-type] Journal Article

[Publication-country] Australia

[Chemical-registry-number] 0 / DNA, Viral

   

7. |......... 7%  de Mendonça MC, Ferreira AM, dos Santos MG, Oviedo EC, Bello MS, Siqueira MM, Maceira JM, von Hubinger MG, Couceiro JN: Genotyping of human parvovirus B19 in clinical samples from Brazil and Paraguay using heteroduplex mobility assay, single-stranded conformation polymorphism and nucleotide sequencing. Mem Inst Oswaldo Cruz; 2011 Jun;106(4):502-4

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[Title] Genotyping of human parvovirus B19 in clinical samples from Brazil and Paraguay using heteroduplex mobility assay, single-stranded conformation polymorphism and nucleotide sequencing.

Heteroduplex mobility assay, single-stranded conformation polymorphism and nucleotide sequencing were utilised to genotype human parvovirus B19 samples from Brazil and Paraguay.

Ninety-seven serum samples were collected from individuals presenting with abortion or erythema infectiosum, arthropathies, severe anaemia and transient aplastic crisis; two additional skin samples were collected by biopsy.

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[Affiliation] Instituto de Microbiologia Prof. Paulo de Góes, Centro de Ciências da Saúde, Brasil.

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[ISSN] 1678-8060

[Journal-full-title] Memórias do Instituto Oswaldo Cruz

[ISO-abbreviation] Mem. Inst. Oswaldo Cruz

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Brazil

   

8. |......... 6%  Blaise G, Nikkels AF, Piérard GE: [Cutaneous manifestations of parvovirus B19 infection]. Rev Med Liege; 2007 Jul-Aug;62(7-8):492-5

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[Title] [Cutaneous manifestations of parvovirus B19 infection].

[Transliterated title] Manifestations cutanées de l'infection par le parvovirus B19.

The human parvovirus B19 is a small single-strand DNA virus with specific tropism for the membranous receptor P expressed on erythrocytes and endothelial cells.

About 60 - 70 % of the adult population is parvovirus B19 seropositive.

This review focuses on its cutaneous manifestations including erythema infectiosum, and the purpuric syndromes whose principal manifestation is the papulo-purpuric gloves and socks syndrome.

Several other cutaneous manifestations have been reported to be associated with the parvovirus B19 without however strong evidence.

These include vasculitis, erythema nodosum, the lupus eythematosus-like syndrome, some vesiculo-pustular eruptions, pityriasis lichenoides and scleroderma.

[MeSH-major] Erythema Infectiosum / diagnosis

[MeSH-minor] Diagnosis, Differential. Humans. Parvovirus B19, Human. Skin / virology

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[Affiliation] Service de Dermatopathologie, CHU du Sart Tilman, Liège, Belgique.

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[ISSN] 0370-629X

[Journal-full-title] Revue médicale de Liège

[ISO-abbreviation] Rev Med Liege

[Language] fre

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] Belgium

[Number-of-references] 26

   

9. |......... 6%  Edmonson MB, Riedesel EL, Williams GP, Demuri GP: Generalized petechial rashes in children during a parvovirus B19 outbreak. Pediatrics; 2010 Apr;125(4):e787-92

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Generalized petechial rashes in children during a parvovirus B19 outbreak.

OBJECTIVES: Human parvovirus B19 infection is associated not only with erythema infectiosum (fifth disease) but also, rarely, with purpuric or petechial rashes.

During a community outbreak of fifth disease, we investigated a cluster of illnesses in children with generalized petechial rashes to determine whether parvovirus was the causative agent and, if so, to describe more fully the clinical spectrum of petechial rashes that are associated with this virus.

METHODS: Systematic evaluation was conducted by general pediatricians of children with petechial rashes for evidence of acute parvovirus infection.

RESULTS: During the outbreak, acute parvovirus infection was confirmed in 13 (76%) of 17 children who were evaluated for petechial rash.

Parvovirus immunoglobulin M was detected in 8 (73%) of 11 acute-phase serum specimens, and immunoglobulin G was detectable only in convalescent specimens.

Parvovirus DNA was detected in all 7 tested serum specimens, including 2 acute-phase specimens that were immunoglobulin M-negative.

Two case patients developed erythema infectiosum during convalescence.

CONCLUSIONS: During an outbreak of fifth disease, parvovirus proved to be a common cause of petechial rash in children, and this rash was typically more generalized than described in case reports.

Associated clinical features, hematologic abnormalities, and serologic test results are consistent with a viremia-associated illness that is distinct from and occasionally followed by erythema infectiosum.

[MeSH-major] Disease Outbreaks. Erythema Infectiosum / epidemiology. Exanthema / epidemiology. Parvovirus B19, Human. Purpura / epidemiology

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[Affiliation] Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. edmonson@pediatrics.wisc.edu send email

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[ISSN] 1098-4275

[Journal-full-title] Pediatrics

[ISO-abbreviation] Pediatrics

[Language] eng

[Publication-type] Comparative Study; Journal Article

[Publication-country] United States

   

10. |......... 6%  Opstelten W, Eekhof JA, Knuistingh Neven A: [Childhood diseases with exanthema]. Ned Tijdschr Geneeskd; 2011;155(41):A3671

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Childhood diseases with exanthema].

- Due to high vaccination coverage, measles and rubella (German measles) are now rarely seen in the Netherlands, which makes recognition of these diseases difficult.

- Swift recognition of measles and rubella is necessary in order to manage them adequately and to prevent spreading of the disease.

- Measles, rubella, and erythema infectiosum ('fifth disease') may result in complications during pregnancy.

- Measles, rubella, scarlet fever, erythema infectiosum, and roseola ('sixth disease') can be difficult to differentiate.

- In the Netherlands, diagnosis of a patient with measles or rubella, or of more than 1 patient with erythema infectiosum within one institution, must be reported to the local health authority within 1 working day.

- Exclusion from school or a day-care facility is not required for any if the diseases discussed.

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[Affiliation] Nederlands Huisartsen Genootschap, afd. Richtlijnontwikkeling en Wetenschap, Utrecht, The Netherlands. w.opstelten@nhg.org send email

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[ISSN] 1876-8784

[Journal-full-title] Nederlands tijdschrift voor geneeskunde

[ISO-abbreviation] Ned Tijdschr Geneeskd

[Language] dut

[Publication-type] English Abstract; Journal Article

[Publication-country] Netherlands

   

11. |......... 6%  Frotscher B, Salignac S, Morlon L, Bonmati C, Jeulin H, Venard V, Lecompte T: [Neutropenia and/or thrombocytopenia due to acute parvovirus B19 infection]. Ann Biol Clin (Paris); 2009 May-Jun;67(3):343-8

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[Title] [Neutropenia and/or thrombocytopenia due to acute parvovirus B19 infection].

[Transliterated title] Neutropénie et/ou thrombopénie associée(s) à une infection aiguë par le parvovirus B19.

Erythema infectiosum (fifth disease) is the most common clinical presentation of acute parvovirus B19 infection in infancy.

In healthy adults, most cases of infection are asymptomatic or accompanied by a flu-like syndrome like headaches and myalgia.

Patients with sickle cell disease, thalassemia or other disorders associated with shortened red blood cell survival are at particular risk for marked anemia or red blood cell aplasia.

Neutropenia, lymphopenia or thrombocytopenia have also been reported in acute parvovirus B19 infection.

We present two patients with thrombopenia and/or neutropenia but without anemia due to acute parvovirus B19 infection.

[MeSH-major] Erythema Infectiosum / blood. Erythema Infectiosum / diagnosis. Neutropenia / virology. Parvoviridae Infections / blood. Parvoviridae Infections / diagnosis. Parvovirus B19, Human / isolation & purification. Thrombocytopenia / virology

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[Affiliation] Service d'hématologie biologique, CHU de Nancy. b.frotscher@chu-nancy.fr send email

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[ISSN] 0003-3898

[Journal-full-title] Annales de biologie clinique

[ISO-abbreviation] Ann. Biol. Clin. (Paris)

[Language] fre

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] France

   

12. |......... 6%  Servey JT, Reamy BV, Hodge J: Clinical presentations of parvovirus B19 infection. Am Fam Physician; 2007 Feb 1;75(3):373-6

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[Title] Clinical presentations of parvovirus B19 infection.

Although most persons with parvovirus B19 infection are asymptomatic or have mild, nonspecific, cold-like symptoms, several clinical conditions have been linked to the virus.

Parvovirus B19 usually infects children and causes the classic "slapped-cheek" rash of erythema infectiosum (fifth disease).

The virus also may cause acute or persistent arthropathy and papular, purpuric eruptions on the hands and feet ("gloves and socks" syndrome) in adults.

Parvovirus B19 infection can trigger an acute cessation of red blood cell production, causing transient aplastic crisis, chronic red cell aplasia, hydrops fetalis, or congenital anemia.

This is even more likely in patients with illnesses that have already shortened the lifespan of erythrocytes (e.g., iron deficiency anemia, human immunodeficiency virus, sickle cell disease, thalassemia, spherocytosis).

A clinical diagnosis can be made without laboratory confirmation if erythema infectiosum is present.

[MeSH-major] Parvoviridae Infections / diagnosis. Parvovirus B19, Human

[MeSH-minor] Adult. Anemia, Aplastic / etiology. Child. Erythema Infectiosum / diagnosis. Female. Humans. Hydrops Fetalis / etiology. Joint Diseases / etiology. Male. Pregnancy. Red-Cell Aplasia, Pure / etiology

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[Affiliation] David Grant Medical Center, Travis Air Force Base, California 94535, USA. jessica.servey@travis.af.mil send email

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[ISSN] 0002-838X

[Journal-full-title] American family physician

[ISO-abbreviation] Am Fam Physician

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Number-of-references] 23

   

13. |......... 5%  Waza K, Inoue K, Matsumura S: Symptoms associated with parvovirus B19 infection in adults: a pilot study. Intern Med; 2007;46(24):1975-8

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Symptoms associated with parvovirus B19 infection in adults: a pilot study.

BACKGROUND AND OBJECTIVES: The clinical features of parvovirus B19 infection in adult patients have not been well described.

The aim of this prospective study was to clarify the clinical features of adult patients with parvovirus B19 infection in primary care settings.

They were chosen if they had at least two of the following three symptoms: edema, joint pain, and rash, and if they had contact with children with erythema infectiosum.

The diagnosis was confirmed if anti-parvovirus B19 antibodies were identified.

RESULTS: Twenty patients met the inclusion criteria, and 14 (70%) patients were diagnosed with parvovirus B19 infection.

In the first group, they presented with the first phase of infection showing symptoms such as malaise, muscle pain, and fever, and in the second phase presented with edema, rash, and joint pain that developed within two days of the first phase.

CONCLUSIONS: Parvovirus B19 infection in adults can be efficiently diagnosed in primary care settings by observing clinical symptoms such as edema, joint pain, and rash, and by asking patients about their contact with children who have erythema infectiosum.

[MeSH-major] Arthralgia / etiology. Edema / etiology. Erythema Infectiosum / complications. Exanthema / etiology. Parvovirus B19, Human / pathogenicity

[MeSH-minor] Adult. Antibodies, Viral / blood. Disease Progression. Female. Humans. Male. Middle Aged. Pilot Projects. Prospective Studies

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[Affiliation] Waza Clinic, Matsudo. QZD10356@nifty.ne.jp send email

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[ISSN] 1349-7235

[Journal-full-title] Internal medicine (Tokyo, Japan)

[ISO-abbreviation] Intern. Med.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Antibodies, Viral

   

14. |......... 5%  Suzuki M, Yoto Y, Ishikawa A, Tsutsumi H: Analysis of nucleotide sequences of human parvovirus B19 genome reveals two different modes of evolution, a gradual alteration and a sudden replacement: a retrospective study in Sapporo, Japan, from 1980 to 2008. J Virol; 2009 Nov;83(21):10975-80

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Analysis of nucleotide sequences of human parvovirus B19 genome reveals two different modes of evolution, a gradual alteration and a sudden replacement: a retrospective study in Sapporo, Japan, from 1980 to 2008.

There have been no long-term systematic analyses of the molecular epidemiology of human parvovirus B19 (B19V).

In that period, six outbreaks of erythema infectiosum occurred regularly at 5-year intervals.

[MeSH-major] Base Sequence. DNA, Viral / analysis. Erythema Infectiosum. Evolution, Molecular. Genome, Viral. Parvovirus B19, Human / genetics

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[Affiliation] Department of Pediatrics, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo 060-8543, Japan.

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[ISSN] 1098-5514

[Journal-full-title] Journal of virology

[ISO-abbreviation] J. Virol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / DNA, Viral

[Other-IDs] NLM/ PMC2772762

   

15. |......... 5%  Kumano K: [Various clinical symptoms in human parvovirus B19 infection]. Nihon Rinsho Meneki Gakkai Kaishi; 2008 Dec;31(6):448-53

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Various clinical symptoms in human parvovirus B19 infection].

Human parvovirus B19 infection causes erythema infectiosum in child, aplastic crisis in patients with chronic hemolytic anemia, chronic pure red cell aplasia in immunocompromised patients and hydrops fetalis.

Human parvovirus B19 causes arthritis and acute glomerulonephritis due to immunological mechanism.

Other disorders, rheumatoid arthritis, vasculitis and thrombotic microangiopathy, are linked in human parvovirus B19 infection.

Parvovirus B19 infection causes choronic rheumatoid-like arthropathy.

Autoantibody and low complement were seen in acute human parvovirus infection, and parvovirus B19 infection present clinically lupus like tableau.

[MeSH-major] Parvoviridae Infections / complications. Parvovirus B19, Human

[MeSH-minor] Antibody Formation. Arthritis, Rheumatoid / etiology. Autoantibodies. Erythema Infectiosum / etiology. Glomerulonephritis / etiology. Humans

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[Affiliation] Pulmonary Medicine and Clinical Immunology, Dokkyo University School of Medicine.

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[ISSN] 1349-7413

[Journal-full-title] Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology

[ISO-abbreviation] Nihon Rinsho Meneki Gakkai Kaishi

[Language] jpn

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] Japan

[Chemical-registry-number] 0 / Autoantibodies

[Number-of-references] 47

   

16. |......... 5%  Le Scanff J, Vighetto A, Mekki Y, Nguyen AM, Dufour JF, Broussolle C, Seve P: Acute ophthalmoparesis associated with human parvovirus B19 infection. Eur J Ophthalmol; 2010 Jul-Aug;20(4):802-4

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Acute ophthalmoparesis associated with human parvovirus B19 infection.

PURPOSE: Parvovirus B19 infection (PVB19) has been linked with a broad spectrum of clinical syndromes.

In addition to erythema infectiosum and asymptomatic infection, other less common manifestations include transient aplastic crisis in patients with hemoglobinopathies, pure red cell aplasia and pancytopenia in immunocompromised persons, nonimmune hydrops fetalis, chronic arthritis, myocarditis, and hepatitis.

METHODS: Only 19% of patients had peripheral nervous system damage, mainly including brachial plexitis and carpal tunnel syndrome.

We report the first case of acute ophthalmoparesis associated with PVB19 infection.

[MeSH-major] DNA, Viral / analysis. Erythema Infectiosum / complications. Ophthalmoplegia / etiology. Parvovirus B19, Human / genetics

[MeSH-minor] Acute Disease. Adult. Diagnosis, Differential. Humans. Male. Polymerase Chain Reaction. Tomography, X-Ray Computed

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[Affiliation] Department of Internal Medicine, Hospices Civils de Lyon, and University Claude Bernard, Lyon 1, France.

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[ISSN] 1120-6721

[Journal-full-title] European journal of ophthalmology

[ISO-abbreviation] Eur J Ophthalmol

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Italy

[Chemical-registry-number] 0 / DNA, Viral

   

17. |......... 5%  Greco F, Barbagallo ML, Chiodo DC, Guglielmino R, Sorge G: Severe ataxia as a complication of human parvovirus B19 acute encephalitis in a child. J Child Neurol; 2008 Sep;23(9):1078-80

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Severe ataxia as a complication of human parvovirus B19 acute encephalitis in a child.

Human parvovirus B19 generally causes erythema infectiosum in childhood, but it can be associated with unusual findings, particularly in immunocompromised patients.

This is a report about an immunocompetent 4-year-old female child affected with acute encephalitis by parvovirus B19, documented by polymerase chain reaction performed on cerebrospinal fluid, who was treated with intravenous immunoglobulins and dexamethasone and who developed a cerebellar syndrome with ataxia, dysmetria, and dysarthria.

To the best of the authors' knowledge, this may be the first report of human parvovirus B19 encephalitis complicated by severe ataxia in childhood.

[MeSH-major] Ataxia / virology. Cerebellar Ataxia / virology. Encephalitis, Viral / complications. Encephalitis, Viral / virology. Parvoviridae Infections / complications. Parvoviridae Infections / virology. Parvovirus B19, Human / immunology

[MeSH-minor] Anti-Inflammatory Agents / therapeutic use. Cerebellum / physiopathology. Cerebellum / virology. Child, Preschool. Dexamethasone / therapeutic use. Disease Progression. Female. Humans. Immunoglobulins, Intravenous / therapeutic use. Magnetic Resonance Imaging. Occipital Lobe / pathology. Occipital Lobe / physiopathology. Occipital Lobe / virology. Parietal Lobe / pathology. Parietal Lobe / physiopathology. Parietal Lobe / virology. RNA, Viral / genetics. RNA, Viral / isolation & purification. Treatment Failure

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[Affiliation] Department of Pediatrics, University of Catania, Catania, Italy. coicoico@hotmail.com send email

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[ISSN] 1708-8283

[Journal-full-title] Journal of child neurology

[ISO-abbreviation] J. Child Neurol.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Anti-Inflammatory Agents; 0 / Immunoglobulins, Intravenous; 0 / RNA, Viral; 50-02-2 / Dexamethasone

   

18. |......... 5%  Servant-Delmas A, Lefrère JJ, Morinet F, Pillet S: Advances in human B19 erythrovirus biology. J Virol; 2010 Oct;84(19):9658-65

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[Title] Advances in human B19 erythrovirus biology.

Since its discovery, human parvovirus B19 (B19V), now termed erythrovirus, has been associated with many clinical situations (neurological and myocardium infections, persistent B19V DNAemia) in addition to the prototype clinical manifestations, i.e., erythema infectiosum and erythroblastopenia crisis.

In 2002, the use of new molecular tools led to the characterization of three different genotypes of human B19 erythrovirus.

Although the genomic organization is conserved, the geographic distribution of the different genotypes varies worldwide, and the nucleotidic divergences can impact the molecular diagnosis of B19 virus infection.

[MeSH-major] Parvoviridae Infections / etiology. Parvovirus B19, Human / genetics. Parvovirus B19, Human / pathogenicity

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[Affiliation] Département des Agents Transmissibles par le Sang, Institut National de la Transfusion Sanguine, Paris, France.

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[ISSN] 1098-5514

[Journal-full-title] Journal of virology

[ISO-abbreviation] J. Virol.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] United States

[Number-of-references] 102

[Other-IDs] NLM/ PMC2937825

   

19. |......... 5%  Bonvicini F, La Placa M, Manaresi E, Gallinella G, Gentilomi GA, Zerbini M, Musiani M: Parvovirus b19 DNA is commonly harboured in human skin. Dermatology; 2010;220(2):138-42

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Parvovirus b19 DNA is commonly harboured in human skin.

BACKGROUND: Parvovirus B19 is the aetiological agent of erythema infectiosum.

The presence of B19 DNA in lesional skin of other cutaneous manifestations has frequently been reported although there is disagreement on the role of the B19 virus in tissues.

OBJECTIVES: To investigate the presence of B19 DNA (1) in skin lesions of patients with a described B19-related disease, (2) in skin lesions of B19-unrelated diseases and (3) in healthy skin.

METHODS: A total of 121 skin samples were examined for the presence of B19 DNA by PCR assays and peptide-nucleic-acid-based in situ hybridisation techniques.

RESULTS: B19 DNA was detected in 11/38 (28.9%) pityriasis lichenoides, 8/30 (26.7%) melanocytic naevi, 5/29 (17.2%) primary melanomas and 6/24 (25.0%) healthy skin biopsies.

A difference in B19 DNA prevalence was observed in specimens grouped according to age, irrespective of pathologies.

CONCLUSIONS: B19 DNA can be found in skin tissues of patients with pityriasis lichenoides as well as in lesions not related to B19 infection and in healthy controls.

B19 DNA can be detected in skin of young subjects in a significantly high rate compared to adults, suggesting that viral persistence may be the usual outcome after primary infection.

[MeSH-major] Erythema Infectiosum / virology. Parvovirus B19, Human / isolation & purification. Skin / virology

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[Affiliation] Division of Microbiology, University of Bologna, Bologna, Italy. francesca.bonvicini4@unibo.it send email

[CommentIn] Dermatology. 2010;220(2):186-8 [20110634.001]

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[ISSN] 1421-9832

[Journal-full-title] Dermatology (Basel, Switzerland)

[ISO-abbreviation] Dermatology (Basel)

[Language] eng

[Publication-type] Journal Article

[Publication-country] Switzerland

[Chemical-registry-number] 0 / DNA, Viral

   

20. |......... 5%  Oiwa H, Shimada T, Hashimoto M, Kawaguchi A, Ueda T, Sugiyama E, Kamiya T: Clinical findings in parvovirus B19 infection in 30 adult patients in Kyoto. Mod Rheumatol; 2011 Feb;21(1):24-31

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Clinical findings in parvovirus B19 infection in 30 adult patients in Kyoto.

To relate the clinical findings of parvovirus B19 infection to the phase of the disease, we performed a retrospective chart review of 30 adult patients who tested positive for IgM antibody against parvovirus B19 at our hospital from March 2003 to November 2008.

The onsets in 73.3% of cases were concentrated within 10.1% of the study period, an observation nearly consistent with an outbreak of erythema infectiosum.

In the parvovirus B19 infection, flu-like symptoms were frequent in the first phase, while rash and arthralgia were common in the second.

Female sex, age between 26 and 45, and presence of rash, arthralgia, fever, and lymphopenia were clinical findings with a high frequency (≥70%), and these factors may contribute to diagnosis.

In an era when early diagnosis and therapy is required in rheumatoid arthritis, it is important to recognize the parvovirus B19 infection with a presentation of acute arthritis and a favorable prognosis.

[MeSH-major] Arthralgia / pathology. Edema / pathology. Erythema Infectiosum / pathology. Parvovirus B19, Human / pathogenicity

[MeSH-minor] Adult. Aged. Disease Outbreaks. Female. Humans. Male. Middle Aged. Retrospective Studies

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[Affiliation] Department of General Internal Medicine, Rakuwakai Otowa Hospital, Otowachinji-cho 2, Yamashina-ku, Kyoto, 607-8062, Japan. hiroshioiwa@aol.com send email

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[ISSN] 1439-7609

[Journal-full-title] Modern rheumatology / the Japan Rheumatism Association

[ISO-abbreviation] Mod Rheumatol

[Language] eng

[Publication-type] Journal Article

[Publication-country] Japan

   

21. |......... 5%  Waldman M, Kopp JB: Parvovirus-B19-associated complications in renal transplant recipients. Nat Clin Pract Nephrol; 2007 Oct;3(10):540-50

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Parvovirus-B19-associated complications in renal transplant recipients.

Parvovirus B19 is a common human pathogen, causing erythema infectiosum in children, hydrops fetalis in pregnant women, and transient aplastic crisis in patients with chronic hemolytic anemia.

Immunosuppressed patients can fail to mount an effective immune response to B19, resulting in prolonged or persistent viremia.

Renal transplant recipients can develop symptomatic B19 infections as a result of primary infection acquired via the usual respiratory route or via the transplanted organ, or because of reactivation of latent or persistent viral infection.

The most common manifestations of B19 infection in immunosuppressed patients are pure red cell aplasia and other cytopenias.

Thus, this diagnosis should be considered in transplant recipients with unexplained anemia and reticulocytopenia or pancytopenia.

Collapsing glomerulopathy and thrombotic microangiopathy have been reported in association with B19 infection in renal transplant recipients, but a causal relationship has not been definitively established.

Prompt diagnosis of B19 infection in the renal transplant recipient requires a high index of suspicion and careful selection of diagnostic tests, which include serologies and polymerase chain reaction.

[MeSH-minor] Disease Transmission, Infectious. Erythema Infectiosum / complications. Erythema Infectiosum / diagnosis. Erythema Infectiosum / etiology. Erythema Infectiosum / therapy. Herpesviridae Infections / complications. Humans. Immunoglobulins, Intravenous / therapeutic use. Immunosuppressive Agents / administration & dosage. Immunosuppressive Agents / adverse effects. Red-Cell Aplasia, Pure / virology

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[Affiliation] Kidney Disease Section, National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20814-9692, USA. merylw@intra.niddk.nih.gov send email

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[ISSN] 1745-8331

[Journal-full-title] Nature clinical practice. Nephrology

[ISO-abbreviation] Nat Clin Pract Nephrol

[Language] eng

[Publication-type] Journal Article; Research Support, N.I.H., Intramural; Review

[Publication-country] England

[Chemical-registry-number] 0 / Immunoglobulins, Intravenous; 0 / Immunosuppressive Agents

[Number-of-references] 99

   

22. |......... 5%  Mylonas I, Gutsche S, Anton G, Jeschke U, Weissenbacher ER, Friese K: [Parvovirus B 19 infection during pregnancy]. Z Geburtshilfe Neonatol; 2007 Apr;211(2):60-8

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Parvovirus B 19 infection during pregnancy].

[Transliterated title] Parvovirus-B 19-Infektion in der Schwangerschaft.

The parvovirus B 19 is part of the family of the parvoviridae and shows a distinctive tropism for erythropoid precursor cells.

The virus causes in children the erythema infectiosum (German measles).

Meanwhile, parvovirus B 19 infections can be associated with a wide spectrum of hematological and non-hematological complications (e.g. liver failure, hepatitis, aplastic crises primarily in association with chronic hemolytic anaemias, chronic arthritis, arthralgia/arthritis, transient/persistent anaemias, vasculitis, glomerulonephritis).

Intrauterine infections can lead to specific or permanent organ defects (e.g. heart anomalies, eye diseases, micrognathy, chronic anaemia, myocarditis, hepatitis, mekonium peritonitis and central nervous system anomalies).

Parvovirus B 19 infections are also associated with hydrops fetalis and intrauterine death during pregnancy.

A definite relation between fetal malformations and B 19 infection has not been accomplished yet.

Pregnancies complicated by parvovirus B 19 infection should be followed for further exclusion of any teratogenic effect.

Although congenital malformations after a parvovirus infection are possible, this phenomenon seems to be rare.

Investigation for the development and clinical testing of an efficient vaccine against parvovirus B 19 is currently in progress.

[MeSH-major] Erythema Infectiosum / diagnosis. Parvoviridae Infections / diagnosis. Parvovirus B19, Human / pathogenicity. Pregnancy Complications, Infectious / diagnosis

[MeSH-minor] Congenital Abnormalities / etiology. Female. Fetal Death / etiology. Hematologic Diseases / etiology. Humans. Hydrops Fetalis / etiology. Infant, Newborn. Pregnancy. Prenatal Care. Prognosis. Risk Assessment. Virulence

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[Affiliation] Frauenklinik München--Klinikum Innenstadt, Ludwig Maximilians Universität, München, Germany. ioannis.mylonas@med.uni-muenchen.de send email

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[ISSN] 0948-2393

[Journal-full-title] Zeitschrift für Geburtshilfe und Neonatologie

[ISO-abbreviation] Z Geburtshilfe Neonatol

[Language] ger

[Publication-type] English Abstract; Journal Article; Review

[Publication-country] Germany

[Number-of-references] 109

   

23. |......... 5%  Ermoloich MA, Semeĭko GV, Samoĭlovich EO, Hubschen JM, Muller CP: [Molecular epidemiology of parvovirus infection in Belarus]. Vopr Virusol; 2010 Mar-Apr;55(2):26-31

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Molecular epidemiology of parvovirus infection in Belarus].

The paper analyzes a 994 nucleotide fragment of the NS1/VP1u region junction of 84 parvovirus B19 samples obtained from the sera of erythema infectiosum patients in Belarus in 2006.

Cluster 1A mainly included B19 strains from Minsk where an outbreak of erythema infectiosum was observed during sample collection.

Cluster 1B comprises parvovirus B19 strains obtained from sporadic cases in different parts of the country.

The comparison of the Belarus strains with all parvovirus B19 sequences from the GenBank revealed 22 unique nucleotide substitutions in the new strains, 18 (81.8%) of which were nonsynonymous.

A high percentage of parvovirus B19 IgM positive sera were also PCR positive (94.0%; n = 63/67) indicating that both methods are suitable for diagnosis of the infection.

[MeSH-major] Parvoviridae Infections / epidemiology. Parvovirus B19, Human / genetics

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[ISSN] 0507-4088

[Journal-full-title] Voprosy virusologii

[ISO-abbreviation] Vopr. Virusol.

[Language] rus

[Publication-type] English Abstract; Journal Article

[Publication-country] Russia (Federation)

[Chemical-registry-number] 0 / Viral Nonstructural Proteins; 0 / Viral Structural Proteins

   

24. |......... 5%  Lunardi C, Tinazzi E, Bason C, Dolcino M, Corrocher R, Puccetti A: Human parvovirus B19 infection and autoimmunity. Autoimmun Rev; 2008 Dec;8(2):116-20

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Human parvovirus B19 infection and autoimmunity.

Human parvovirus B19 infection is responsible for a wide range of human diseases ranging from mild erythema infectiosum in immunocompetent children to fetal loss in primary infected pregnant women and aplastic anemia or lethal cytopenias in adult immunocompromised patients.

Since persistent viral infection is responsible for an autoimmune response and clinical symptoms can mimic autoimmune inflammatory disorders, parvovirus B19 is the object of intense efforts to clarify whether it is also able to trigger autoimmune diseases.

Indeed the virus has been implicated as the causative or the precipitating agent of several autoimmune disorders including rheumatoid arthritis, systemic lupus, antiphospholipid syndrome, systemic sclerosis and vasculitides.

By means of a random peptide library approach, we have identified a peptide that shares homology with parvovirus VP1 protein and with human cytokeratin.

These new data sustain the role played by molecular mimicry in the induction of cross-reactive (auto)antibodies by parvovirus B19 infection.

[MeSH-major] Autoimmunity / immunology. Cross Reactions / immunology. Erythema Infectiosum / immunology. Molecular Mimicry / immunology. Parvovirus B19, Human / immunology

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[Affiliation] Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Verona, Italy. claudio.lunardi@univr.it send email

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[ISSN] 1873-0183

[Journal-full-title] Autoimmunity reviews

[ISO-abbreviation] Autoimmun Rev

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Netherlands

[Number-of-references] 40

   

25. |......... 4%  Milosević V, Jerant-Patić V, Hrnjaković-Cvjetković I, Vukmanović-Papuga M, Jelena RT, Kovacević G: [The frequency of human parvovirus B19 infections in Vojvodina]. Med Pregl; 2007 Nov-Dec;60(11-12):575-9

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [The frequency of human parvovirus B19 infections in Vojvodina].

INTRODUCTION: Human parvovirus B19 is found worldwide.

It causes various infections, including fifth disease (erythema infectiosum) in small children, acute arthropathy in adults, transient aplastic crisis and chronic anemia in immunocompromised patients and even fetal infection, which may result in intrauterine fetal death or fetal hydrops.

Many of these manifestations of B19 infection are caused by infection of erythroid precursor cells in bone marrow.

MATERIAL AND METHODS: The aim of this paper was to establish the frequency of parvovirus B19 infection in the population of Vojvodina, as well as to indicate the significance of further investigations particularly in highly vulnerable population groups such as small children, pregnant women and immune deficient persons.

A total of 244 serum samples of out- and in-patients of different age were analyzed using SERION ELISA classic parvovirus B19 IgG/IgM quantitative and qualitative tests for identification of specific antibodies against human parvovirus B19.

RESULTS: Acute infection was found in 35% of examinees, whereas parvoviurs B19 was identified in 32% of examined persons.

Our tests results proved that 20% of examined pregnant women in our surroundings have acute HPB19 infection.

At the same time, 45% of pregnant women have no specific antibodies, so they are at risk of infection during pregnancy.

Acute infection was diagnosed in 41 children (43%): 22 samples (23%) were positive only to IgG antibodies and in 32 samples (34%) neither IgM nor IgG antibodies were identified.

Acute infection was more frequently found in preschool children, i.e. in children aged 4 to 6 years (29%).

CONCLUSION: In the absence of complete data on the frequency of particular diseases caused by this virus in our population, tests for human parvovirus B19 are strongly recommended.

[MeSH-major] Erythema Infectiosum / epidemiology. Parvoviridae Infections / epidemiology. Parvovirus B19, Human

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[Affiliation] Institut zajavno zdravlje Vojvodine.

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[ISSN] 0025-8105

[Journal-full-title] Medicinski pregled

[ISO-abbreviation] Med. Pregl.

[Language] srp

[Publication-type] English Abstract; Journal Article

[Publication-country] Serbia

[Chemical-registry-number] 0 / Antibodies, Viral

   

26. |......... 4%  Nara M, Shirata Y, Kikuchi T, Hongo M: Adult human parvovirus-B19 infection presenting with hearing difficulty and dizziness. Tohoku J Exp Med; 2011;224(1):57-9

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Adult human parvovirus-B19 infection presenting with hearing difficulty and dizziness.

Human parvovirus B19 (HPV-B19), a small and non-enveloped DNA virus, causes erythema infectiosum (EI) in children.

We diagnosed her as HPV-B19 infection after her daughter's history and positive test for serum HPV-B19 IgM antibody, together with the continued observations.

HPV-B19 IgM antibody value (2.4) measured after one month of the onset was decreased to 1.7, 1.1, and 0.9 after two, three, and five months of the onset, respectively.

Her symptoms gradually improved along with the decrease in HPV-B19 antibody without any medication.

Hearing difficulty and dizziness are not categorized as manifestations of HPV-B19 infection, because these symptoms are very rare.

The present report indicates that the symptoms related to inner ear dysfunctions should be added to those associated with adult HPV-B19 infection.

In conclusion, we should consider HPV-B19 infection when we evaluate patients with causeless hearing difficulty and dizziness.

[MeSH-major] Dizziness / etiology. Hearing Loss / etiology. Parvoviridae Infections / complications. Parvoviridae Infections / immunology. Parvovirus B19, Human / immunology

[MeSH-minor] Adult. Antibodies, Viral / blood. Child. Erythema Infectiosum / physiopathology. Erythema Infectiosum / virology. Female. Humans. Immunoglobulin M / blood. Immunoglobulin M / immunology

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[Affiliation] Division of Comprehensive Medicine, Department of Internal Medicine, Tohoku University Hospital, Aoba-ku, Sendai, Japan. nara@hosp.tohoku.ac.jp send email

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[ISSN] 1349-3329

[Journal-full-title] The Tohoku journal of experimental medicine

[ISO-abbreviation] Tohoku J. Exp. Med.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

[Chemical-registry-number] 0 / Antibodies, Viral; 0 / Immunoglobulin M

   

27. |......... 4%  von Landenberg P, Lehmann HW, Modrow S: Human parvovirus B19 infection and antiphospholipid antibodies. Autoimmun Rev; 2007 Apr;6(5):278-85

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Human parvovirus B19 infection and antiphospholipid antibodies.

Erythema infectiosum is the main manifestation of human parvovirus B19 infections.

Further B19-related diseases commonly associated with the acute infection are flue-like symptoms, transient aplastic crisis, transient arthralgias, leukopenia and thrombocytopenia, spontaneous abortion and hydrops fetalis in pregnant women.

In addition parvovirus B19 infections have been frequently described as cause or trigger of various forms of autoimmune diseases affecting all blood cell lines, joints, connective tissue, uvea, large and small vessels.

These mechanisms implicated in the pathogenesis of parvovirus B19 triggered autoimmune diseases, especially focused on the development of antiphospholipid antibodies will be discussed in this short review.

[MeSH-major] Antibodies, Antiphospholipid / immunology. Parvoviridae Infections / immunology. Parvovirus B19, Human

[MeSH-minor] Autoimmune Diseases / virology. Female. Humans. Pregnancy. Pregnancy Complications, Infectious / immunology

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[Affiliation] Institut für Klinische Chemie und Laboratoriumsmedizin, Johannes Gutenberg Universität Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany. landenberg@zentrallabor.klinik.uni-mainz.de send email

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[ISSN] 1568-9972

[Journal-full-title] Autoimmunity reviews

[ISO-abbreviation] Autoimmun Rev

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] Netherlands

[Chemical-registry-number] 0 / Antibodies, Antiphospholipid

[Number-of-references] 36

   

28. |......... 4%  Kamlesh Y, Pallav G, Manjula M, Rohan M: Seizure and hepatosplenomegaly-rare manifestation of parvovirus B-19: a case report and review of the literature. J Trop Med; 2011;2011:287914

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Seizure and hepatosplenomegaly-rare manifestation of parvovirus B-19: a case report and review of the literature.

Parvovirus B19 is the etiologic agent of erythema infectiosum (fifth disease), a fever-rash illness occurring in childhood.

EBV serology and parvovirus PCR were also performed.

Bone marrow aspiration and biopsy showed giant pro-erythroblast consistent with parvovirus infection.

PCR showed amplification of parvovirus genomic sequences.

Present case highlights an atypical presentation of Parvovirus B19 infection as fever, rash and hepatosplenomegaly.

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[Affiliation] Department of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India.

[Cites] Clin Microbiol Rev. 2002 Jul;15(3):485-505 [12097253.001]

[Cites] J Trop Pediatr. 2009 Oct;55(5):335-7 [19203989.001]

[Cites] J Pediatr. 1970 Jul;77(1):133-6 [4317884.001]

[Cites] Arch Dis Child. 1993 Jun;68(6):784-5 [8333774.001]

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[ISSN] 1687-9694

[Journal-full-title] Journal of tropical medicine

[ISO-abbreviation] J Trop Med

[Language] eng

[Publication-type] Journal Article

[Publication-country] Egypt

[Other-IDs] NLM/ PMC3134170

   

29. |......... 4%  Wan Z, Zhi N, Wong S, Keyvanfar K, Liu D, Raghavachari N, Munson PJ, Su S, Malide D, Kajigaya S, Young NS: Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors. J Clin Invest; 2010 Oct 1;120(10):3530-44

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors.

Human parvovirus B19 (B19V) is the only human pathogenic parvovirus.

It causes a wide spectrum of human diseases, including fifth disease (erythema infectiosum) in children and pure red cell aplasia in immunocompromised patients.

Current understanding of how B19V interacts with cellular factors to regulate disease progression is limited, due to a lack of permissive cell lines and animal models.

Here, we employed a recently developed primary human CD36(+) EPC culture system that is highly permissive for B19V infection to identify cellular factors that lead to cell cycle arrest after B19V infection.

[MeSH-major] E2F Transcription Factors / physiology. Erythroid Precursor Cells / cytology. Parvovirus B19, Human / pathogenicity

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[Affiliation] Hematology Branch, National Heart, Lung, and Blood Institute, NIH, Bethesda, Maryland 20892-1652, USA.

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[ISSN] 1558-8238

[Journal-full-title] The Journal of clinical investigation

[ISO-abbreviation] J. Clin. Invest.

[Language] eng

[Publication-type] Journal Article; Research Support, N.I.H., Intramural

[Publication-country] United States

[Chemical-registry-number] 0 / Antigens, CD36; 0 / E2F Transcription Factors; 0 / E2F4 Transcription Factor; 0 / E2F4 protein, human; 0 / E2F5 Transcription Factor; 0 / E2F5 protein, human; 0 / NS1 protein, parvovirus; 0 / Tumor Suppressor Protein p53; 0 / Viral Nonstructural Proteins

[Other-IDs] NLM/ PMC2947219

   

30. |......... 3%  Elnifro E, Nisha AK, Almabsoot M, Daeki A, Mujber N, Muscat J: Seroprevalence of parvovirus B19 among pregnant women in Tripoli, Libya. J Infect Dev Ctries; 2009;3(3):218-20

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[Title] Seroprevalence of parvovirus B19 among pregnant women in Tripoli, Libya.

BACKGROUND: Human parvovirus B19 has been implicated as a primary etiologic agent of erythema infectiosum (fifth disease) and aplastic crisis in patients with chronic haemolytic anemias.

Human parvovirus B19 is known to be associated with adverse effects on fetuses such as hydrops fetalis, intrauterine fetal death, and chronic anaemia in immunocompromized individuals.

The objective of this study was to assess the seroprevalence of human parvovirus B19 among the pregnant women in Tripoli, Libya.

CONCLUSION: The presence of IgG and absence of IgM indicate immunity to primary infection, but a significant percentage of child-bearing aged women are at risk of primary infection with parvovirus B19 which could adversely affect their pregnancy.

[MeSH-major] Parvoviridae Infections / epidemiology. Parvovirus B19, Human / immunology. Pregnancy Complications, Infectious / epidemiology

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[Affiliation] Department of Medical Microbiology, Medical School, University of Al-Marghib, Al-Kums, Libya. adl@mail.lttnet.net send email

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[ISSN] 1972-2680

[Journal-full-title] Journal of infection in developing countries

[ISO-abbreviation] J Infect Dev Ctries

[Language] eng

[Publication-type] Journal Article

[Publication-country] Italy

[Chemical-registry-number] 0 / Antibodies, Viral; 0 / Immunoglobulin G; 0 / Immunoglobulin M

   

31. |......... 3%  Emiasegen SE, Nimzing L, Adoga MP, Ohagenyi AY, Lekan R: Parvovirus B19 antibodies and correlates of infection in pregnant women attending an antenatal clinic in central Nigeria. Mem Inst Oswaldo Cruz; 2011 Mar;106(2):227-31

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Parvovirus B19 antibodies and correlates of infection in pregnant women attending an antenatal clinic in central Nigeria.

Human parvovirus B19 infection is associated with spontaneous abortion, hydrops foetalis, intrauterine foetal death, erythema infectiosum (5th disease), aplastic crisis and acute symmetric polyarthropathy.

However, data concerning Nigerian patients with B19 infection have not been published yet.

The purpose of this study was to establish the prevalence of B19 IgG and IgM antibodies, including correlates of infection, among pregnant women attending an antenatal clinic in Nigeria.

Significant determinants of infection (p < 0.05) included the receipt of a blood transfusion, occupation and the presence of a large number of children in the household.

Routine screening for B19 IgM antibodies and accompanying clinical management of positive cases should be made mandatory for all Nigerian blood donors and women of childbearing age.

[MeSH-major] Antibodies, Viral / blood. Immunoglobulin G / blood. Immunoglobulin M / blood. Parvoviridae Infections / epidemiology. Parvovirus B19, Human / immunology. Pregnancy Complications, Infectious / epidemiology

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[Affiliation] Department of Medical Microbiology, University of Jos, Plateau State, Nigeria.

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[ISSN] 1678-8060

[Journal-full-title] Memórias do Instituto Oswaldo Cruz

[ISO-abbreviation] Mem. Inst. Oswaldo Cruz

[Language] eng

[Publication-type] Journal Article

[Publication-country] Brazil

[Chemical-registry-number] 0 / Antibodies, Viral; 0 / Immunoglobulin G; 0 / Immunoglobulin M

   

32. |......... 3%  Weissbrich B, Süss-Fröhlich Y, Girschick HJ: Seroprevalence of parvovirus B19 IgG in children affected by juvenile idiopathic arthritis. Arthritis Res Ther; 2007;9(4):R82

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Seroprevalence of parvovirus B19 IgG in children affected by juvenile idiopathic arthritis.

Parvovirus (PV) B19 is the causative agent of the childhood disease erythema infectiosum.

An association of PV B19 with chronic arthropathies, sometimes resembling rheumatoid arthritis or juvenile idiopathic arthritis (JIA), has repeatedly been described.

In order to study further whether there is a link between PV B19 and JIA, we determined the prevalence of PV B19 specific IgG antibodies in serum samples from children with rheumatoid diseases and compared it with the prevalence in unaffected children We reasoned that if there is an association between PV B19 and JIA, then the prevalence of PV B19 IgG in the children with JIA should be higher than in the control group.

PV B19 IgG status was tested in 406 children with JIA and related diseases, and in 146 children constituting a control group.

The percentage of PV B19 IgG positive children was not significantly elevated in the disease subgroups compared with age-matched control groups.

In conclusion, our findings do not support the hypothesis that human parvovirus B19 is involved in the pathogenesis of JIA.

[MeSH-major] Antibodies, Viral / blood. Arthritis, Juvenile Rheumatoid / immunology. Arthritis, Juvenile Rheumatoid / virology. Immunoglobulin G / blood. Parvoviridae Infections / immunology. Parvovirus B19, Human / immunology

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[Affiliation] Institute of Virology and Immunobiology, University of Würzburg, Versbacher Str 7, 97078 Würzburg, Germany. weissbrich@vim.uni-wuerzburg.de send email

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[ISSN] 1478-6362

[Journal-full-title] Arthritis research & therapy

[ISO-abbreviation] Arthritis Res. Ther.

[Language] eng

[Publication-type] Journal Article

[Publication-country] England

[Chemical-registry-number] 0 / Antibodies, Viral; 0 / Immunoglobulin G

[Other-IDs] NLM/ PMC2206386

   

33. |......... 3%  Goncalves G, Dias M: Parvovirus outbreak in a kindergarten in a municipality in the north of Portugal, April-June 2008. Euro Surveill; 2008 Nov 27;13(48)

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Parvovirus outbreak in a kindergarten in a municipality in the north of Portugal, April-June 2008.

The intention was to establish an aetiological diagnosis and take corrective measures if necessary.

Blood samples from seven children with facial erythema were collected for serological investigation.

Seventeen cases of erythema infectiosum, due to infection with parvovirus B19, were identified and classified as "confirmed".

This parvovirus B19 outbreak made it possible to estimate the basic reproduction number (R0) at between 6 and 8 (or above).

Staff members, parents and local clinicians were informed that the infection could pose a risk when caught by people with special clinical conditions.

The seven children with serologically confirmed parvovirus B19 infection were immune to measles and rubella.

[MeSH-major] Child Day Care Centers / statistics & numerical data. Disease Outbreaks / statistics & numerical data. Parvoviridae Infections / epidemiology. Parvovirus B19, Human. Population Surveillance. Risk Assessment / methods

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[Affiliation] Local Public Health Unit, Vila Nova de Famalicao, Portugal. gg@csfamalicao1.min-saude.pt send email

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[ISSN] 1560-7917

[Journal-full-title] Euro surveillance : bulletin européen sur les maladies transmissibles = European communicable disease bulletin

[ISO-abbreviation] Euro Surveill.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Sweden

   

34. |......... 3%  Bernstein DI, El Sahly HM, Keitel WA, Wolff M, Simone G, Segawa C, Wong S, Shelly D, Young NS, Dempsey W: Safety and immunogenicity of a candidate parvovirus B19 vaccine. Vaccine; 2011 Oct 6;29(43):7357-63

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Safety and immunogenicity of a candidate parvovirus B19 vaccine.

Parvovirus B19 is an important human pathogen causing erythema infectiosum, transient aplastic crisis in individuals with underlying hemolytic disorders and hydropsfetalis.

We therefore evaluated a parvovirus B19 virus like particle (VLP) vaccine.

The safety and immunogenicity of a 25 μg dose of parvovirus B19 recombinant capsid; 2.5 and 25 μg doses of the recombinant capsid given with MF59; and saline placebo were assessed in healthy adults.

After dose 2 the majority of vaccine recipients developed ELISA and neutralizing antibody to parvovirus B19.

Given the possible severe consequences of parvovirus B19 infection, further development of a safe and effective vaccine continues to be important.

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[Affiliation] Cincinnati Chidren's Hospital Medical Center, University of Cincinnati, 3333 Burnet Ave., ML 6014, Cincinnati, OH 45229, United States. David.Bernstein@cchmc.org send email

[Copyright] Copyright © 2011 Elsevier Ltd. All rights reserved.

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[ISSN] 1873-2518

[Journal-full-title] Vaccine

[ISO-abbreviation] Vaccine

[Language] eng

[Grant] United States / NIAID NIH HHS / AI / AI 25465; United States / NIAID NIH HHS / AI / AI 45248

[Publication-type] Journal Article; Research Support, N.I.H., Extramural

[Publication-country] Netherlands

[Other-IDs] NLM/ NIHMS319358 [Available on 10/06/12]; NLM/ PMC3186820 [Available on 10/06/12]

   

35. |......... 3%  Lehmann HW, Plentz A, von Landenberg P, Küster RM, Modrow S: Different patterns of disease manifestations of parvovirus B19-associated reactive juvenile arthritis and the induction of antiphospholipid-antibodies. Clin Rheumatol; 2008 Mar;27(3):333-8

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Different patterns of disease manifestations of parvovirus B19-associated reactive juvenile arthritis and the induction of antiphospholipid-antibodies.

Children with rheumatic oligo- and polyarthritis frequently establish persistent parvovirus B19 infections, which may be associated with the production of antiphospholipid antibodies.

Reported in this paper are the data of five girls with polyarticular rheumatic diseases of different types and persistent parvovirus B19 infection associated in four cases with the presence of antibodies against phospholipids.

In two patients, erythema infectiosum preceded the development of arthritis and B19 viremia persisted.

Two other girls showed antibodies against parvoviral structural proteins at time of the manifestation of the rheumatic disease.

Subsequent samples also revealed persistent B19 infection.

In the fifth patient, parvovirus B19-specific IgG antibodies were detected for the first time after 120 months of progressing disease at an age of 11 1/2 years.

In a synovial tissue specimen subsequently obtained, parvovirus B19 structural proteins could be detected by immunohistochemistry.

The fifth patient suffers from progressive erosions despite intensive therapeutical efforts.

In consequence, parvovirus B 19 should generally be taken into consideration as a trigger of various forms of juvenile arthritis and persistence of infection should be evaluated.

[MeSH-major] Antibodies, Antiphospholipid / immunology. Arthritis / virology. Arthritis, Juvenile Rheumatoid / virology. Parvoviridae Infections / immunology. Parvovirus B19, Human / immunology

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[Affiliation] Department of Pediatrics, University of Giessen, Giessen, Germany. hartwig.lehmann@paediat.med.uni-giessen.de send email

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[ISSN] 0770-3198

[Journal-full-title] Clinical rheumatology

[ISO-abbreviation] Clin. Rheumatol.

[Language] eng

[Publication-type] Case Reports; Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] Belgium

[Chemical-registry-number] 0 / Antibodies, Antiphospholipid; 0 / Immunosuppressive Agents

   

36. |......... 3%  Reinheimer C, Allwinn R, Doerr HW, Wittek M: Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors. Infection; 2010 Oct;38(5):381-5

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors.

BACKGROUND: Parvovirus B 19 is a virus that is distributed by respiratory droplets.

It is known to be an initiator of erythema infectiosum (children's fifth disease), with erythroblasts being the target cells of infection.

OBJECTIVE: Parvovirus B19 seroprevalence was investigated in serum samples routinely collected from patients who had been admitted to the University Hospital in Frankfurt a.

M., Germany. Patients were classified in different groups in order to analyze parovirus B19 seroprevalences in terms of risk factors.

MATERIALS AND METHODS: Between June 2007 and March 2010, a total of 2,197 serum samples were analyzed for parvovirus B19-immunoglobulin G using an enzyme-linked immunosorbent assay.

The study population included six groups of patients, namely, patients suffering from haemophilia, malignant disease, immunodeficiency diseases, common gynecological ailments, pregnant women and children with malignant diseases.

RESULTS: Of the 2,197 serum samples, 1,383 contained antibodies to parvovirus B19 (62.9%).

We found a positive serostatus in 54.9% of adult patients with malignant disease, in 64.2% of patients with haemophilia (1 to ≥60 years), in 66.7% of patients under immunosuppression with various drugs (1 to ≥60 years) and in 41.7% of oncological patients aged 1-19 years.

CONCLUSION: The seroprevalence of parvovirus B19 in patients admitted to the University Hospital in Frankfurt a.M. was, on average, lower than that among the general population in Germany.

Infection among patients in specific risk groups did not spread more than that in age-matched non-selected patients, with the exception of the group of immunocompromised patients.

[MeSH-major] Parvoviridae Infections / epidemiology. Parvoviridae Infections / immunology. Parvovirus B19, Human / immunology

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[Affiliation] Institute for Medical Virology, JW Goethe University Hospital, 60596 Frankfurt am Main, Germany. claudia.reinheimer@kgu.de send email

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[ISSN] 1439-0973

[Journal-full-title] Infection

[ISO-abbreviation] Infection

[Language] eng

[Publication-type] Journal Article

[Publication-country] Germany

[Chemical-registry-number] 0 / Antibodies, Viral; 0 / Immunoglobulin G

   

37. |......... 3%  Pugliese A, Beltramo T, Torre D, Roccatello D: Parvovirus B19 and immune disorders. Cell Biochem Funct; 2007 Nov-Dec;25(6):639-41

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Parvovirus B19 and immune disorders.

Parvovirus B19 (PVB19) is the causative agent of erythema infectiosum and sometimes the infection is correlated with severe haematological complications, or in pregnancy to fetalis hydrops.

Moreover some authors suggest an infection involvement in some autoimmune diseases.

The data reported here can confirm a possible correlation between PVB19 prior infection and LES and also suggest possible implications in the case of cryoglobulinemia.

[MeSH-major] Autoimmune Diseases / epidemiology. Parvoviridae Infections / epidemiology. Parvovirus B19, Human / immunology

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[Affiliation] Department of Medical and Surgical Sciences, Clinical Microbiology University of Turin, Amedeo di Savoia Hospital, Turin, Italy. agostino.pugliese@unito.it send email

[Copyright] Copyright (c) 2006 John Wiley & Sons, Ltd.

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[ISSN] 0263-6484

[Journal-full-title] Cell biochemistry and function

[ISO-abbreviation] Cell Biochem. Funct.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / Antibodies, Viral; 0 / Immunoglobulin G

   

38. |......... 3%  Schenk T, Enders M, Pollak S, Hahn R, Huzly D: High prevalence of human parvovirus B19 DNA in myocardial autopsy samples from subjects without myocarditis or dilative cardiomyopathy. J Clin Microbiol; 2009 Jan;47(1):106-10

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] High prevalence of human parvovirus B19 DNA in myocardial autopsy samples from subjects without myocarditis or dilative cardiomyopathy.

Human parvovirus B19 has been linked to a variety of cardiac diseases, as well as to erythema infectiosum, acute arthropathy, and fetal hydrops.

A causal association between viral infection and cardiac disease was frequently postulated following the detection of B19 DNA by PCR in endomyocardial biopsy specimens.

Since the lifelong persistence of B19 DNA in bone marrow, skin, synovia, tonsils, and liver was previously reported, the aim of our study was to investigate the possibility of asymptomatic B19 DNA persistence in heart tissue.

All study subjects were screened for B19-specific antibodies using a commercial enzyme immunoassay.

Since the presence of B19 genotype 2, known to have been circulating before 1960, would prove long-lasting persistence, the presence of the B19 genotype was retrospectively determined in seven of the study subjects by melting temperature analysis and sequencing of the PCR product.

B19 DNA was found in myocardial samples from 46 of 48 seropositive and in none of 21 seronegative individuals.

B19 genotype 1 was found in three patients born between 1950 and 1969.

Our findings suggest lifelong persistence of B19 DNA in heart tissue.

Thus, the detection of B19 DNA in myocardial biopsy specimens alone is not sufficient to postulate a relationship between B19 infection and cardiac disease.

[MeSH-major] Autopsy. Heart / virology. Myocardium / pathology. Parvoviridae Infections / virology. Parvovirus B19, Human / isolation & purification

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[Affiliation] Department of Virology, University Medical Center, Freiburg, Hermann-Herder-Str. 11, 79104 Freiburg, Germany.

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[ISSN] 1098-660X

[Journal-full-title] Journal of clinical microbiology

[ISO-abbreviation] J. Clin. Microbiol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antibodies, Viral; 0 / DNA, Viral

[Other-IDs] NLM/ PMC2620852

   

39. |......... 3%  Meyer P, Jeziorski E, Bott-Gilton L, Foulongne V, Rivier F, Rondoin G, Rodière M: [Childhood parvovirus B19 encephalitis]. Arch Pediatr; 2011 Dec;18(12):1310-4

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Childhood parvovirus B19 encephalitis].

[Transliterated title] Encéphalite à parvovirus B19 de l'enfant.

INTRODUCTION: Human parvovirus B19 (PVB19) causes erythema infectiosum or 5(th) disease in childhood, which mainly affects children between 3 and 15 years of age.

The diagnosis of encephalitis associated with PVB19 primo infection was based on viral DNA detection in the serum and CSF using PCR and on the specific immunoglobulin M (without immunoglobulin G) detection in the serum.

CONCLUSION: Even if PVB19 research is not cited in the French or American infectious disease society recommendations on the diagnosis and management of infectious encephalitis, this virus may be responsible, especially in cases of child febrile rash.

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[Affiliation] Service d'immuno-rhumatologie et maladies infectieuses pédiatriques, université Montpellier-1, CHU de Montpellier, 34000 Montpellier, France; Service de neuropédiatrie, université Montpellier-1, CHU de Montpellier, 34000 Montpellier, France.

[Copyright] Copyright © 2011 Elsevier Masson SAS. All rights reserved.

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[ISSN] 1769-664X

[Journal-full-title] Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie

[ISO-abbreviation] Arch Pediatr

[Language] fre

[Publication-type] English Abstract; Journal Article

[Publication-country] France

   

40. |......... 3%  Hashimoto H, Yuno T: Parvovirus B19-associated purpuric-petechial eruption. J Clin Virol; 2011 Nov;52(3):269-71

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Parvovirus B19-associated purpuric-petechial eruption.

BACKGROUND: Papular-purpuric gloves-and-socks syndrome, characterized by focal acral purpuric eruptions with a symmetrical distribution, is a rare but representative purpuric dermatosis closely associated with parvovirus B19 (PVB19) infection.

Such multifaceted features can cause considerable confusion when making a diagnosis of purpuric eruption associated with PVB19.

OBJECTIVES: Describe two febrile patients with atypical presentation of papular-purpuric eruptions due to PVB19 infection and discuss the distinctive features of purpuric-petechial eruptions associated with PVB19 infection.

STUDY DESIGN: Case reports and viral diagnosis by serologic tests and real-time PCR for PVB19 DNA in the serum.

Both cases were followed by erythema infectiosum.

Paired serum antibody analysis and real-time PCR indicated the link between the development of papular purpuric eruption and the viremic phase of primary PVB19 infection.

CONCLUSIONS: PVB19 infection should be considered in any patient presenting with a petechial or purpuric eruption of unclear origin, and not solely for PPGSS type presentations.

Therefore, we propose a simple name "PVB19-associated purpuric-petechial eruption" to describe polymorphous purpuric-petechial eruptions due to PVB19 infection, coinciding with the viremic phase of primary infection and infectivity, characterized by a self-limiting course with a benign prognosis and common histological findings.

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[Affiliation] Department of Pediatrics, Kanazawa Red Cross Hospital, 2-251 Minma, Kanazawa 921-8162, Japan. doct1189@kanazawa-rc-hosp.jp send email

[Copyright] Copyright © 2011 Elsevier B.V. All rights reserved.

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[ISSN] 1873-5967

[Journal-full-title] Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

[ISO-abbreviation] J. Clin. Virol.

[Language] eng

[Publication-type] Journal Article

[Publication-country] Netherlands

   

41. |......... 3%  Regaya F, Oussaief L, Bejaoui M, Karoui M, Zili M, Khelifa R: Parvovirus B19 infection in Tunisian patients with sickle-cell anemia and acute erythroblastopenia. BMC Infect Dis; 2007;7:123

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Parvovirus B19 infection in Tunisian patients with sickle-cell anemia and acute erythroblastopenia.

BACKGROUND: Human parvovirus B19 is the etiologic agent of erythema infectiosum in children.

Patients with chronic hemolytic anemia are at high risk of developing acute erythroblastopenia following infection by the virus.

Close monitoring of such high risk groups is required for epidemiologic surveillance and disease prevention activities.

Here we report a molecular epidemiological study on B19 virus infection in Tunisian patients with chronic hemolytic anemia.

Screening for IgM and IgG anti-B19 antibodies was performed using commercially available enzyme immunoassays and B19 DNA was detected by nested PCR in the overlapping VP1/VP2 region.

RESULTS: Anti-parvovirus B19 IgG antibodies were detected in 26 of 46 sickle-cell anemia patients, 18 of 46 beta-thalassemia and 7 of 46 controls.

Anti-parvovirus B19 IgM antibodies were detected only in 4 of the sickle-cell anemia patients: two siblings and two unrelated who presented with acute erythroblastopenia at the time of blood collection for this study and had no history of past transfusion.

B19 DNA was detected only in sera of these four patients and the corresponding 288 bp nested DNA amplicons were sequenced.

The sequences obtained were all identical and phylogenetic analysis showed that they belonged to a new B19 virus strain of Genotype1.

CONCLUSION: A new parvovirus B19 strain of genotype1 was detected in four Tunisian patients with sickle-cell anemia.

The possibility of independent transmission of this B19 variant to the patients is unlikely in light of the present epidemiological data.

[MeSH-major] Anemia, Sickle Cell / complications. Parvoviridae Infections / epidemiology. Parvovirus B19, Human / isolation & purification. Red-Cell Aplasia, Pure / virology

[MeSH-minor] Adolescent. Adult. Base Sequence. Child. Cross Infection / complications. Cross Infection / epidemiology. Cross Infection / virology. DNA, Viral / chemistry. Erythroblasts / cytology. Humans. Male. Molecular Sequence Data. Phylogeny. Sequence Alignment. Tunisia / epidemiology

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[Affiliation] Viral and Molecular Tumor Diagnostics Unit, Habib Thameur Hospital, 1008 Tunis, Tunisia. faouzi.regaya@rns.tn send email

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[ISSN] 1471-2334

[Journal-full-title] BMC infectious diseases

[ISO-abbreviation] BMC Infect. Dis.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] England

[Chemical-registry-number] 0 / DNA, Viral

[Other-IDs] NLM/ PMC2151067

   

42. |......... 3%  Mogensen TH, Jensen JM, Hamilton-Dutoit S, Larsen CS: Chronic hepatitis caused by persistent parvovirus B19 infection. BMC Infect Dis; 2010;10:246

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Chronic hepatitis caused by persistent parvovirus B19 infection.

BACKGROUND: Human infection with parvovirus B19 may lead to a diverse spectrum of clinical manifestations, including benign erythema infectiosum in children, transient aplastic crisis in patients with haemolytic anaemia, and congenital hydrops foetalis.

These different diseases represent direct consequences of the ability of parvovirus B19 to target the erythroid cell lineage.

CASE PRESENTATION: Here, we present an unusual case of persistent parvovirus B19 infection as a cause of chronic hepatitis.

This patient had persistent parvovirus B19 viraemia over a period of more than four years and displayed signs of chronic hepatitis evidenced by fluctuating elevated levels of ALAT and a liver biopsy demonstrating chronic hepatitis.

In addition, the patient was evaluated for immunodeficiency, since she had lymphopenia both prior to and following clearance of parvovirus B19 infection.

CONCLUSIONS: In this case report, we describe the current knowledge on the natural history and pathogenesis of parvovirus B19 infection, and discuss the existing evidence of parvovirus B19 as a cause of acute and chronic hepatitis.

We suggest that parvovirus B19 was the direct cause of this patient's chronic hepatitis, and that she had an idiopathic lymphopenia, which may have predisposed her to persistent infection, rather than bone marrow depression secondary to infection.

Finally, we suggest that clinicians should be aware of parvovirus B19 as an unusual aetiology of chronic hepatitis, when other causes have been ruled out.

[MeSH-major] Hepatitis, Chronic / diagnosis. Hepatitis, Chronic / virology. Parvoviridae Infections / diagnosis. Parvoviridae Infections / pathology. Parvovirus B19, Human / isolation & purification

[MeSH-minor] Alanine Transaminase / blood. Biopsy. Female. Histocytochemistry. Humans. Liver / pathology. Lymphopenia / complications. Lymphopenia / diagnosis. Microscopy. Middle Aged. Viremia

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[Affiliation] Department of Infectious Diseases, Aarhus University Hospital, Skejby, DK-8200 Aarhus N, Denmark. trine.mogensen@dadlnet.dk send email

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[ISSN] 1471-2334

[Journal-full-title] BMC infectious diseases

[ISO-abbreviation] BMC Infect. Dis.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] England

[Chemical-registry-number] EC 2.6.1.2 / Alanine Transaminase

[Other-IDs] NLM/ PMC2936411

   

43. |......... 3%  Pinto V, Grandy J, Zambrano P, Corta B, Salas P, Salgado I, Santander J, Salgado C, Chadid J, Iñiguez R: Severe anemia from parvovirus b19 infection in pediatric renal transplant recipients: two case reports. Transplant Proc; 2008 Nov;40(9):3261-4

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Severe anemia from parvovirus b19 infection in pediatric renal transplant recipients: two case reports.

Human parvovirus B19 (PVB19) is the etiologic agent of erythema infectiosum (fifth disease), a common childhood exanthema.

Herein we have reported our experience with two pediatric renal transplant recipients who had severe pure red cell aplasia in the early period after surgery, accompanying PVB19 infection.

A bone marrow aspirate confirmed a PVB19 infection by PCR.

CONCLUSIONS: The presence of persistent anemia in immunocompromised hosts with a low reticulocyte count suggests PVB19 infection.

[MeSH-major] Anemia / etiology. Ganciclovir / therapeutic use. Immunoglobulins, Intravenous / therapeutic use. Kidney Transplantation / adverse effects. Parvoviridae Infections / diagnosis. Parvoviridae Infections / drug therapy. Parvovirus B19, Human

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[Affiliation] Exequiel González Cortés Hospital, Metropolitan Southern Health Service, Pediatric Department, University of Chile School of Medicine, Santiago, Chile. violaps@gmail.com send email

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[ISSN] 0041-1345

[Journal-full-title] Transplantation proceedings

[ISO-abbreviation] Transplant. Proc.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] United States

[Chemical-registry-number] 0 / Antiviral Agents; 0 / Immunoglobulins, Intravenous; 60-27-5 / Creatinine; 82410-32-0 / Ganciclovir

   

44. |......... 2%  Chen YC, Chen MY, Lu CY, Chang HH, Hung CC, Chen MY, Chen ML: Cluster of parvovirus infection among hospital staff working in coronary care units. J Formos Med Assoc; 2010 Dec;109(12):886-94

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Cluster of parvovirus infection among hospital staff working in coronary care units.

BACKGROUND: Parvovirus B19 is associated with erythema infectiosum in children or arthralgia and arthritis in adults.

Here, we describe the first cluster of parvovirus infection among hospital staff documented in Taiwan.

Serum was tested for parvovirus B19 IgM and IgG by immunoblotting and DNA by nested polymerase chain reaction.

The attack rate was defined as the cumulative incidence of acute infection in CCU staff and patients during the study period.

Three had acute infection as demonstrated by viral DNA and IgM.

A sequence with 45 nucleotide variations was identified from a staff member with chronic infection who was negative for IgM and had only weak IgG anti-VP1 reaction with immunoblotting.

We did not find any patient as the source of infection.

CONCLUSION: We identified a cluster of parvovirus infection that was caused by three circulating strains which did not support the hypothesis of transmission of a single strain in CCUs.

[MeSH-major] DNA, Viral / analysis. Parvoviridae Infections. Parvovirus B19, Human / isolation & purification

[MeSH-minor] Acute Disease. Adult. Aged. Aged, 80 and over. Coronary Care Units / standards. Cross Infection / diagnosis. Cross Infection / epidemiology. Cross Infection / physiopathology. Cross Infection / prevention & control. Cross Infection / transmission. Female. Humans. Incidence. Infection Control / methods. Inpatients. Male. Middle Aged. Personnel, Hospital. Seroepidemiologic Studies. Taiwan

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[Affiliation] Department of Internal Medicine, National Taiwan University Hospital, Taiwan. yeechunchen@gmail.com send email

[Copyright] Copyright © 2010 Formosan Medical Association & Elsevier. Published by Elsevier B.V. All rights reserved.

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[ISSN] 0929-6646

[Journal-full-title] Journal of the Formosan Medical Association = Taiwan yi zhi

[ISO-abbreviation] J. Formos. Med. Assoc.

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't

[Publication-country] China (Republic : 1949- )

[Chemical-registry-number] 0 / DNA, Viral

   

45. |......... 2%  Lamont RF, Sobel JD, Vaisbuch E, Kusanovic JP, Mazaki-Tovi S, Kim SK, Uldbjerg N, Romero R: Parvovirus B19 infection in human pregnancy. BJOG; 2011 Jan;118(2):175-86

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Parvovirus B19 infection in human pregnancy.

Human parvovirus B19 infection is widespread.

Approximately 30-50% of pregnant women are nonimmune, and vertical transmission is common following maternal infection in pregnancy.

Fetal infection may be associated with a normal outcome, but fetal death may also occur without ultrasound evidence of infectious sequelae.

B19 infection should be considered in any case of nonimmune hydrops.

Diagnosis is mainly through serology and polymerase chain reaction.

[MeSH-major] Erythema Infectiosum. Fetal Diseases. Parvovirus B19, Human. Pregnancy Complications, Infectious

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[Affiliation] Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, USA. rlamont@med.wayne.edu send email

[Copyright] © 2010 RCOG No claim to original US government works Journal compilation © RCOG 2010 BJOG An International Journal of Obstetrics and Gynaecology.

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[ISSN] 1471-0528

[Journal-full-title] BJOG : an international journal of obstetrics and gynaecology

[ISO-abbreviation] BJOG

[Language] eng

[Publication-type] Journal Article; Research Support, N.I.H., Extramural; Review

[Publication-country] England

[Other-IDs] NLM/ NIHMS238311 [Available on 01/01/12]; NLM/ PMC3059196 [Available on 01/01/12]

   

46. |......... 2%  Dubois A, Thellier S, Wierzbicka-Hainaut E, Pierre F, Anyfantakis V, Guillet G: [Two cases of baboon-like exanthema in primary parvovirus B19 infection]. Ann Dermatol Venereol; 2010 Nov;137(11):709-12

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Two cases of baboon-like exanthema in primary parvovirus B19 infection].

[Transliterated title] Exanthème à type de « syndrome babouin » au cours d'une primo-infection par le parvovirus B19 : deux cas.

INTRODUCTION: Primary parvovirus B19 infection may present a wide variety of dermatological features.

We report two cases of parvovirus infection presenting as flexural erythema of baboon syndrome induced by various drugs, but associated with purpuric or oedematous features.

In both cases, the diagnosis of primary parvovirus B19 infection was confirmed by positive PCR screening of viral genome and by seroconversion after two weeks.

DISCUSSION: Although initially linked solely with systemic drug toxicity, baboon syndrome has since been reported in connection with other allergens (drug reactions, contact dermatitis, viral and streptococcal infection).

Among these causes, parvovirus B19 infection merits particular interest.

[MeSH-major] Erythema Infectiosum / pathology. Parvovirus B19, Human. Pregnancy Complications, Infectious / pathology

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[Affiliation] CHU de Poitiers, France. anaelle@free.fr send email

[Copyright] Copyright © 2010 Elsevier Masson SAS. All rights reserved.

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[ISSN] 0151-9638

[Journal-full-title] Annales de dermatologie et de vénéréologie

[ISO-abbreviation] Ann Dermatol Venereol

[Language] fre

[Publication-type] Case Reports; English Abstract; Journal Article

[Publication-country] France

   

47. |......... 2%  Hanai S, Komaki H, Sakuma H, Nakagawa E, Sugai K, Sasaki M, Oya Y, Higurashi N, Hamano S: Acute autonomic sensory and motor neuropathy associated with parvovirus B19 infection. Brain Dev; 2011 Feb;33(2):161-5

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Acute autonomic sensory and motor neuropathy associated with parvovirus B19 infection.

We report a 9-year-old girl with acute autonomic sensory and motor neuropathy (AASM) associated with human parvovirus B19 (HPV-B19) infection.

The patient presented with fever, erythema of the entire body, and abdominal pain with vomiting.

The titer of HPV-B19 IgM antibody was significantly elevated.

AASM is very rare in pediatric populations, and there is no report of AASM associated with HPV-B19 infection.

[MeSH-major] Autonomic Nervous System Diseases / etiology. Erythema Infectiosum / complications. Parvovirus B19, Human / pathogenicity

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[Affiliation] Department of Child Neurology, National Center Hospital for Neurology and Psychiatry, National Center of Neurology and Psychiatry, Kodaira, Japan. hanai-s@ncchd.go.jp send email

[Copyright] Copyright © 2010 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

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[ISSN] 1872-7131

[Journal-full-title] Brain & development

[ISO-abbreviation] Brain Dev.

[Language] eng

[Publication-type] Case Reports; Journal Article

[Publication-country] Netherlands

[Chemical-registry-number] 0 / Antibodies, Viral

   

48. |......... 2%  Staroselsky A, Klieger-Grossmann C, Garcia-Bournissen F, Koren G: Exposure to fifth disease in pregnancy. Can Fam Physician; 2009 Dec;55(12):1195-8

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Exposure to fifth disease in pregnancy.

Near the end of the consultation, she asked me about "slapped cheek" disease and pregnancy, as her son had been diagnosed with fifth disease the previous week.

What is the current guideline for pregnant women exposed to parvovirus B19?

ANSWER: The rate of vertical transmission during maternal parvovirus B19 infection is estimated at 33%, with fetal complications occurring in 3% of infected women.

Fetal complications comprising hemolysis, anemia, and nonimmune hydrops fetalis and fetal loss are more frequent when maternal infection occurs before 20 weeks of gestation.

The first step in the management of this patient would be to obtain immunoglobulin (Ig) M and IgG titres against parvovirus to evaluate if the patient has had previous immunity against the disease.

If results are negative for IgG but positive for IgM (ie, primary infection), this patient would need close obstetrical monitoring for the following weeks, including serial ultrasounds to rule out fetal anemia and hydrops fetalis.

[MeSH-major] Erythema Infectiosum. Pregnancy Complications, Infectious

[MeSH-minor] Adult. Antibodies, Viral / analysis. Diagnosis, Differential. Female. Humans. Incidence. North America / epidemiology. Parvovirus B19, Human / immunology. Pregnancy. Pregnancy Outcome. Risk Factors

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[Affiliation] Hospital for Sick Children in Toronto, Ont.

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[ISSN] 1715-5258

[Journal-full-title] Canadian family physician Médecin de famille canadien

[ISO-abbreviation] Can Fam Physician

[Language] eng

[Publication-type] Journal Article; Research Support, Non-U.S. Gov't; Review

[Publication-country] Canada

[Chemical-registry-number] 0 / Antibodies, Viral

[Number-of-references] 18

[Other-IDs] NLM/ PMC2793222

   

49. |......... 1%  Nagafuji K, Okamura T: [Series, diagnosis at a glance]. Nihon Naika Gakkai Zasshi; 2011 Jan 10;100(1):215-7

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] [Series, diagnosis at a glance].

[MeSH-major] Erythema Infectiosum / diagnosis

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[Affiliation] Division of Hematology and Oncology, Department of Medicine, Kurume University School of Medicine, Japan.

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[ISSN] 0021-5384

[Journal-full-title] Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine

[ISO-abbreviation] Nippon Naika Gakkai Zasshi

[Language] jpn

[Publication-type] Case Reports; Journal Article

[Publication-country] Japan

   

50. |......... 1%  de Jong EP, Walther FJ, Kroes AC, Oepkes D: Parvovirus B19 infection in pregnancy: new insights and management. Prenat Diagn; 2011 May;31(5):419-25

[Source] The source of this record is MEDLINE®, a database of the U.S. National Library of Medicine.

[Title] Parvovirus B19 infection in pregnancy: new insights and management.

In this article, we review the virology, pathology, epidemiology and clinical spectrum of intrauterine human parvovirus B19 (B19V) infection, including intrauterine fetal death, non-immune hydrops fetalis, thrombocytopenia and neurological manifestations such as pediatric stroke and perivascular calcifications.

In addition, we discuss the new insights into the neurodevelopmental outcome of intrauterine B19V infection.

Current diagnosis and management of B19V infection is summarized, including a diagnostic and follow-up flowchart for practical clinical use.

[MeSH-major] Erythema Infectiosum. Fetal Death. Parvovirus B19, Human / physiology. Pregnancy Complications, Infectious / diagnosis

[MeSH-minor] Adult. Blood Transfusion, Intrauterine. Female. Gestational Age. Humans. Hydrops Fetalis / epidemiology. Hydrops Fetalis / pathology. Hydrops Fetalis / virology. Nervous System Diseases / embryology. Nervous System Diseases / virology. Pregnancy. Thrombocytopenia / epidemiology. Thrombocytopenia / pathology. Thrombocytopenia / virology

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[Affiliation] Department of Pediatrics, HAGA Hospital, Juliana's Childrens Hospital, The Hague, The Netherlands. d.oepkes@lumc.nl send email

[Copyright] Copyright © 2011 John Wiley & Sons, Ltd.

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[ISSN] 1097-0223

[Journal-full-title] Prenatal diagnosis

[ISO-abbreviation] Prenat. Diagn.

[Language] eng

[Publication-type] Journal Article; Review

[Publication-country] England

[Chemical-registry-number] Parvovirus antenatal infection

   

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